https://mindlab-blog-drafts.pages.dev/tags/pro-inflammatory-cytokines/Recent content in Pro-Inflammatory-Cytokines on MindLAB Neuroscience — Draft ReviewHugo -- 0.156.0en-us2026 Dr. Sydney Ceruto — MindLAB NeuroscienceTue, 05 May 2026 00:00:00 +0000https://mindlab-blog-drafts.pages.dev/posts/inflammatory-depression/Tue, 05 May 2026 00:00:00 +0000https://mindlab-blog-drafts.pages.dev/posts/inflammatory-depression/<h1 id="inflammatory-depression-how-cytokines-shut-down-your-brains-drive-architecture">Inflammatory Depression: How Cytokines Shut Down Your Brain&rsquo;s Drive Architecture</h1> <p><img alt="Compromised blood-brain barrier microvasculature with inflammatory cytokine signaling penetrating the central nervous system — Dr. Sydney Ceruto, MindLAB Neuroscience." loading="lazy" src="https://mindlab-blog-drafts.pages.dev/images/posts/inflammatory-depression-hero.webp"></p> <p>Inflammatory depression is a distinct neurobiological subtype in which chronic peripheral inflammation — elevated IL-6, TNF-alpha, and CRP — penetrates the blood-brain barrier and suppresses dopaminergic transmission in the VTA-to-ventral-striatum circuit. It produces fatigue, brain fog, and flatlined drive even when standard serotonergic strategies partially lift mood.</p>