Mitochondrial Dysfunction Brain | MindLAB Neuroscience
Mitochondrial Dysfunction in Neurons: How Cellular Energy Failure Drives Cognitive Decline Mitochondrial dysfunction in the brain is a progressive failure of neuronal ATP production — driven by electron transport chain Complex I and III impairment — that depletes the adult neural stem cell pool, collapses hippocampal neurogenesis, and produces a cognitive signature measurable in peripheral blood mononuclear cells through proton leak and ATP-production panels. The damage is not diffuse fatigue. It is architectural. ...
