Orbitofrontal Cortex OCD | Dr. Sydney Ceruto, MindLAB
Orbitofrontal Cortex Overvaluation — Why Your Brain Treats Normal Thoughts as Catastrophic The orbitofrontal cortex is the structure that assigns emotional and threat value to incoming information — and in OCD, it does so with miscalibrated catastrophic weight. Hyperactive lateral OFC signaling exaggerates the predicted aversiveness of ordinary thoughts, then drives the ventral striatum into the loop that becomes a compulsion. The intrusive thought is not the problem. The threshold is. ...
