Why Depression Kills Motivation | MindLAB Neuroscience
Why Your Brain Actively Blocks Motivation: The Habenula and Anti-Reward Signaling in Depression Depression kills motivation because your brain runs a circuit that actively blocks it. The lateral habenula — a small structure behind the thalamus — fires tonically in persistent depression, releasing GABA onto VTA dopaminergic neurons and suppressing the approach signal before effort can begin. ...
