Loneliness and Inflammation | MindLAB Neuroscience
How Loneliness Causes Inflammation: The Hidden Health Crisis in Your Brain Loneliness and inflammation run on the same switch. Perceived social isolation activates the conserved transcriptional response to adversity — CTRA — which reprograms circulating immune cells to produce pro-inflammatory cytokines like IL-6 while suppressing antiviral defenses. The loneliness you feel and the inflammation in your bloodwork are one signal, written twice. The same molecular switch that flips on under isolation is the switch restored connection and parasympathetic tone can flip off. ...
