Lack of Sleep and Decision Making | MindLAB Neuroscience

Why Sleep-Deprived Professionals Make Terrible Decisions (And Don’t Realize It) Lack of sleep and decision making collapse together because sleep loss decouples the ventromedial prefrontal cortex — the brain region that integrates emotion with rational analysis — from the amygdala, while the orexin compensatory wake-drive masks the impairment. Confidence rises as judgment quietly fails, and the mismatch never registers in conscious awareness. ...

May 4, 2026 · 10 min · 1939 words · Dr. Sydney Ceruto