https://mindlab-blog-drafts.pages.dev/tags/brain-aging/Recent content in Brain-Aging on MindLAB Neuroscience — Draft ReviewHugo -- 0.156.0en-us2026 Dr. Sydney Ceruto — MindLAB NeuroscienceThu, 23 Apr 2026 00:00:00 +0000https://mindlab-blog-drafts.pages.dev/posts/cognitive-reserve/Thu, 23 Apr 2026 00:00:00 +0000https://mindlab-blog-drafts.pages.dev/posts/cognitive-reserve/<h1 id="what-is-cognitive-reserve-and-how-do-high-performers-build-it-a-neuroscience-framework">What Is Cognitive Reserve and How Do High Performers Build It? A Neuroscience Framework</h1> <p><img alt="Cortical network with compensatory recruitment pattern — Dr. Sydney Ceruto, MindLAB Neuroscience." loading="lazy" src="https://mindlab-blog-drafts.pages.dev/images/posts/cognitive-reserve-slot1.webp"></p> <p>Cognitive reserve is the brain&rsquo;s capacity to sustain function under neural stress by recruiting alternative networks when primary ones degrade. It is built cumulatively over a lifetime through education, occupational complexity, and cognitively demanding leisure — and measured structurally via cortical thickness, hippocampal volume, and white-matter integrity preserved into late life.</p>https://mindlab-blog-drafts.pages.dev/posts/mitochondrial-dysfunction-brain/Thu, 23 Apr 2026 00:00:00 +0000https://mindlab-blog-drafts.pages.dev/posts/mitochondrial-dysfunction-brain/<h1 id="mitochondrial-dysfunction-in-neurons-how-cellular-energy-failure-drives-cognitive-decline">Mitochondrial Dysfunction in Neurons: How Cellular Energy Failure Drives Cognitive Decline</h1> <p><img alt="Mitochondrial dysfunction in neurons — cortical neuron with interior mitochondrial network and electron transport chain complex architecture — Dr. Sydney Ceruto, MindLAB Neuroscience." loading="lazy" src="https://mindlab-blog-drafts.pages.dev/images/posts/mitochondrial-dysfunction-brain-hero.webp"></p> <p>Mitochondrial dysfunction in the brain is a progressive failure of neuronal ATP production — driven by electron transport chain Complex I and III impairment — that depletes the adult neural stem cell pool, collapses hippocampal neurogenesis, and produces a cognitive signature measurable in peripheral blood mononuclear cells through proton leak and ATP-production panels. The damage is not diffuse fatigue. It is architectural.</p>