Why Do I Wake Up at 3am? | Dr. Sydney Ceruto — MindLAB
The 3AM Wake-Up: What the Cortisol-Melatonin Crossover Reveals About Your Stress Load If you wake at 3am with your mind already running, the cause is not insomnia in the clinical sense. It is the melatonin-cortisol crossover — the pre-dawn hormonal handoff — firing earlier than your body’s sleep architecture can absorb. Under chronic stress load, the HPA axis drives a premature cortisol surge that fragments the REM-dominant second half of the night. ...
